Tuesday, 29 December 2015

Scent and bitter leaves retard growth of cancers, boost immune system

Scent and bitter leaves retard growth of cancers, boost immune system

Can regular intake of a herbal preparation made predominately with scent leaf and bitter leaf stop the growth of breast, lung and prostate cancers? CHUKWUMA MUANYA writes

Researchers have found that using scent leaf or sweet basil and bitter leaf in combination or singly could stop the growth of breast, lung and prostate cancers.

They have also found that aqueous extract of bitter leaf (Vernonia amygdalina) could be used as adjuvant in the management of people living with Human Immuno-deficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS); and for restoration of skin colour and form as well as calming and vitalizing the body.

Botanically called Vernonia amygdalina, bitter leaf is of the plant family Compositae. It is called ewuro in Yoruba and onugbu in Ibo. It is a small shrub that grows predominantly in the tropical Africa. In Nigeria, the plant is locally called bitter leaf due to its bitter taste.

Botanically called Ocimum gratissimum, scent leaf or Basil belongs to the mint family Lameacea. It is called effirin in Yoruba and nchuanwu or arigbe in Ibo.

Vernonia amygdalina and Ocimum gratissimum are among the traditionally used herbal plants to treat different ailments. Vernonia amygdalina has been found useful in the ethno therapy of asthma, schistosomiasis, malaria, measles, diarrhoea, tuberculosis, abdominal pain and fever.

Ocimum gratissimum is commonly used in cooking due to its minty aromatic flavour. Traditionally, Ocimum gratissimum has been used for the treatment of headache, diarrhoea, wart worms and kidney infections. The leaves of the African varieties of Ocimum gratissimum are said to contain thymol oil, which has been found to be highly antiseptic and also used to prevent mosquito bite. Vernonia amygdalina and Ocimum gratissimum have been found to have anti-diabetic properties and boost the immune system.

As one of the plants that form a major portion of the naturalist’s pharmacopeia in Nigeria, bitter leaf has been shown to possess diverse therapeutic effects such as anti-malarial, anti-microbial (anti-bacterial, anti-fungal, anti-plasmodial, among others), anti-diabetic and anti-cancer effects. The anti-cancer effect of VA was first shown in human carcinoma of nasopharynx and later in leukemia cells P-388 and L-1210 using the chloroform extract of VA. Different extracts of VA have thus been used in scientific research to reveal the therapeutic properties of this plant.

A new study has found that scent leaf stops breast cancer. The study titled “Ocimum gratissimum retards breast cancer growth and progression and is a natural inhibitor of matrix metalloproteases” was published in Cancer Biology & Therapy journal.

The researchers wrote: “Ocimum genus (a.k.a holy basil or tulsi) is a dietary herb used for its multiple beneficial pharmacologic properties including anti-cancer activity. Here we show that crude extract of Ocimum gratissimum (OG) and its hydrophobic and hydrophilic fractions (HB and HL) differentially inhibit breast cancer cell chemotaxis and chemoinvasion in vitro and retard tumor growth and temporal progression of MCF10ADCIS.com xenografts, a model of human breast comedo-ductal carcinoma in situ (comedo-DCIS).

“OG-induced inhibition of tumor growth was associated with decreases in basement membrane disintegration, angiogenesis and matrix metalloproteases (MMP)-2 and MMP-9 activities as confirmed by in situ gelatin zymography and cleavage of galectin-3. There was also decrease in MMP-2 and MMP-9 activities in the conditioned media of OG-treated MCF10AT1 and MCF10AT1-EIII8 premalignant human breast cancer cells as compared with control.

“The MMP-2 and MMP-9 inhibitory activities of OG were verified in vitro using gelatin, a synthetic fluorogenic peptide and recombinant galectin-3 as MMP substrates. Mice fed on OG-supplemented drinking water showed no adverse effects compared with control. These data suggest that OG is non-toxic and that the anti-cancer therapeutic activity of OG may in part be contributed by its MMP inhibitory activity.”

Also, a Nigerian born Professor of Biology, Ernest Izevbigie has patented a formula made from bitter leaf (Vernonia amygdalina).

This bitter leaf-based formula is a proven anti-diabetic and anti-cancer formula in laboratory and clinical trials. This formula product can also benefit HIV/AIDS patients. It has been patented: U.S. Patent 6,713,098 in 2004 and the second 6,848,604 in 2005.

Izevbigie said: “We found that in using the plant material (from Vernonia amygdalina), some compounds from the extracts were able to inhibit the growth of breast cancer cells. Later through collaborative research, we found they were also effective in other tumor cells.”

Izevbigie explained that evidence from cell culture and animal studies research and reports from individuals reveal that bitter leaf formula supplement may abate or improve the health conditions or symptoms of HIV/AIDS patients including abrosia (wasting away), nausea and vomiting, compromised immune systems etc. Bitter leaf supplement-induced stimulation of the immune system offers hope to many suffering with AIDS related diseases.

The professor further explained that available data shows that bitter leaf extracts might be effective against herpes virus, and against Kaposi sarcomas (KS), a tumour caused by Human herpes virus 8 (HHV8).

Some of the principal chemical compounds found in the bitter leaf herb are known as steroid glycosides – type vernonioside B1. These compounds possess potent anti-parasitic, anti-tumor, anti-inflammatory, and anti-bacterial effects.

Intercedd Health Products (IHP) is blazing the trail with the introduction of Vernonia Ocimum Tea into the Nigerian market. Vernonia Ocimum Tea is made from Vernonia amaygdalina and Ocimum gratissimum.

The indication on the product reads: “Vernonia amaygdalina is a shrub that grows in tropical Africa. It is commonly called bitter leaf because of its bitter taste. The bitterness is as a result of the presence of the sesquiterpenes lactones and steroid glycosides, which are responsible for the activity.

“Ocimum gratissimum, Scent Leaf, is rich in alkaloids, tannins; flavonoid, phytates and oligosaccharides which are responsible for its medicinal properties.
Vernonia Ocimum tea has immense health benefits such as body weight management, easy bowel evacuation, cleansing of the body system and control of body sugar.”

IHP has also developed another immune booster, Immunovit IHP. According to the developer and professor of pharmacognosy, Maurice Iwu, Immunovit-IHP a disease-fighting supplement, designed to boost immunity against a wide variety of ailments, was crafted to combine the health restoring benefits of Ganoderma mushroom, the antioxidant properties of pomegranate fruits and the adaptogenic/immune enhancing effects of Korean ginseng root extract.

Iwu told The Guardian: “Immunovit-IHP is indicated as a general detoxifier and immune system booster. It has been shown to be valuable in the management of chronic diseases including diabetes. The primary active ingredient of Immunovit – IHP is the Asian mushroom, Ganoderma lucidium or also called ‘Reishi’. The major constituents include Ganoderma triterpenoids and polysaccharides which are unique to Reishi and not found in significant quantities in other plants. Over 150 triterpenoids are found in G. lucidium, which are responsible for some of the numerous pharmacological effects associated with the mushroom.

“The second component of Immunovit – IHP is dried extract of the fruits of Punica granatum, which retains the poly-phenols that prevent the harmful effects of singlet oxygen and other pro-inflammatory free radicals that cause tissue damage in diabetes. The formulation also contains aged Korean ginseng, Panax ginseng, an adaptogen with broad spectrum of beneficial activities, including detoxification, cardiotonic health and stress reduction.”

On the major indications of Immunovit IHP, Iwu said: “As immune booster, apart from its acclaimed use to provide non-specific support for whole system and tissue-level repair and recuperation, IMMUNOVIT-IHP increases the immunoglobulin levels, it provides strong body immunity, and the course of chronic diseases may be reversed.

“As antioxidant, IMMUNOVIT-IHP is the miracle solution which acts against the free oxygen radicals-known as the scourge of humanity. Free oxygen radicals have long been known to damage our cellular structures, genes, DNA and RNA causing premature ageing and over 4000 diseases. IMMUNOVIT-IHP removes bad chemicals from the body, promotes new skin to replace the old ones therefore making you look younger all the time.

“As anti-viral, IMMUNOVIT-IHP reduces or stops the growth of all viruses including the dreaded ones by the production of Interferon. IMMUNOVIT-IHP increases killer cells (cells that fight against foreign bodies in the human body) activity, and also stops the immune system from attacking the host tissue.”

On other health benefits, Iwu said: “IMMUNOVIT-IHP is particularly useful in the management of metabolic disorders, or the so-called Metabolic syndrome. Metabolic syndrome (MetS), also known as insulin resistance syndrome or syndrome X, is the name of a group of risk factors that commonly occur together and include hypertension, abdominal obesity, dyslipidemia, and dysglycemia. The use of Immunovit is likely to reduce the risk for the chronic co-morbidities, particularly cardiovascular disease, diabetes, and non-alcoholic fatty liver disease that often occur with elevated blood sugar.

“In summary, as a result of its activity against metabolic disorders, Immunovit can be used in the management of diabetes, obesity, blood pressure, kidney diseases, liver diseases, insomnia and other sleep disorders, ulcer diseases, detoxifier and energizer, anti-allergy, anti – inflammatory, anticoagulant, cardiotonic.”

Meanwhile, scent leaf, since ancient times has been one of the most popular dietary herbs used for its numerous pharmacological properties.

In recent years, resurging interest in its medicinal properties has led to several studies demonstrating its anti-carcinogenic, radiation-protecting and free-radical scavenging activities.

Aqueous extract of Ocimum gratissimum inhibits proliferation, migration, anchorage-independent growth, induction of COX-2 protein and three-dimensional growth and morphogenesis of breast cancer cells, while others have shown that it suppressed A549 lung adenocarcinoma cells’ viability by activation of apoptotic signals and reducing the expression levels of Bcl-2. Ethanolic extracts of Ocimum sanctum were reported to be cytotoxic to mouse Lewis lung carcinoma (LLC) cells and reduced number of tumor nodule formation in LLC-injected mice. Essential oils isolated from Ocimum viride showed cytotoxic and apoptotic activities toward the colonic carcinoma cells COLO 205.

The researchers further stated: “Previously, we compared three species of Ocimum, O. gratissimum, O. sanctum (green) and O. sanctum (purple) and examined their effect on breast cancer and endothelial cell migration. The results showed that aqueous extracts from all species exerted an inhibitory effect on tumor cell migration, but not significantly on endothelial cell migration. OG also reduced tumor size and neoangiogenesis in a MCF10ADCIS.com xenograft, a preclinical model of human breast ductal carcinoma in situ, prompting the need for further evaluation of its breast cancer preventive and therapeutic properties.

“Numerous studies in preclinical cancer models demonstrated the ability of MMP inhibitors to delay primary tumor growth and block metastasis. However, in clinical trials these inhibitors failed due to significant toxicity and limited clinical efficacy. The paradigm shift for MMP functions, from destructive enzymes to cell signaling regulators and disease anti targets28 suggests that the roles of MMPs in disease development are far more complex than originally thought. Hence in cancer MMP activities are probably more relevant during early stages of tumor development with MMP dependent signaling more relevant biologically than ECM degradation.

“In the present study we report that Ocimum gtatissimum inhibits the progression of human breast cancer, which is partly due to its property as natural non-toxic inhibitor of MMP-2/-9 activities.”

Another study published in the journal Evidence-Based Complementary and Alternative Medicine found that extracts of Ocimum gratissimum might be beneficial to lung carcinoma treatment.

The study is titled “Ocimum gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung Adenocarcinoma Cell A549.”

The Taiwanese researchers found: “Ocimum gratissimum (OG) is widely used as a traditional herb for its antibacterial activity in Taiwan. Recently, antitumor effect of OG on breast cancer cell is also reported; however, the effects of OG on human pulmonary adenocarcinoma cell A549 remain unclear. Therefore, we aimed to investigate whether aqueous OG extract (OGE) affects viability of A549 cells and the signals induced by OGE in A549 cells.

“Further investigation showed that OGE enhanced activation of caspase-3, caspase-9 and caspase-8 and increased protein level of Apaf-1 and Bak, but diminished the level of Bcl-2. Additionally, OGE inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) yet enhanced the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 MAP kinase (p38). In conclusion, our findings indicate that OGE suppressed the cell viability of A549 cells, which may result from the activation of apoptotic signaling and the inhibition of anti-apoptotic signaling, suggesting that OGE might be beneficial to lung carcinoma treatment.”

Results of another study published in Journal of Health Care for the Poor and Underserved encouraged the further studies of Ocimum gratissimum as a potential treatment of prostate cancer.

The researchers wrote: “In this study, the antiproliferative activity of the organic solvent-soluble and aqueous extracts of Ocimum gratissimum leaf against the prostate cancer cells PC3·AR were evaluated by their inhibitory effects on the Androgen Receptor (AR) and Survivin protein. Two organic solvent-soluble extracts P2 and P3–2, and a water- soluble extract, PS/PT1, were found to reduce AR and Survivin levels in a time-dependent manner.

“In addition, extract PS/PT1, also exhibited the inhibitory activity in a dose-dependent manner. This is the first time that the inhibitory eff ects of O. gratissimum extracts have been evaluated on the Androgen Receptor (AR) and Survivin protein. The results encouraged the further studies of O. gratissimum as a potential treatment of prostate cancer.”

Researchers have also found that the anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways

The researcher was published in PLOS ONE.

Source:  Guardian News

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Ground-breaking new cancer study on Graviola

Ground-breaking new cancer study on Graviola

Ground-breaking new cancer study on Graviola

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Ground-breaking new cancer study on Graviola shows promise as a possible treatment.
"10000 times stronger killer of CANCER than Chemo".. do share it.. can save many lives, fill up hopes and build confidence in the patients...

A new study on the herb graviola published in the October 2012 issue of Cancer Letter has cancer researchers buzzing. Graviola, the tropical fruit with the unusual nickname "sour sop," stops cancer tumor cells from growing in pancreatic cancer.
Scientists prove the cancer-healing abilities of graviola in the lab and in living tissue. Oncologists agree that pancreatic cancer is one of the most difficult types of cancer to treat, and that being diagnosed with cancer of the pancreas is as good as a death sentence. The new study, performed by a cancer research team at the Department of Biochemistry and Molecular Biology at the University of Nebraska Medical Center, shows that graviola kills pancreatic cancer cells by inhibiting cellular metabolism. This cancer tumor-fighting ability has been confirmed both in test tubes and in live subjects.
In addition, Graviola works by inhibiting numerous signaling pathways that manage how pancreatic cancer cells grow, how long they live, and how the cancer tumors spread within the host. By altering these parameters, the rate of new cancer cell growth and spread of the disease slowed significantly.
The team of researchers considers the characteristics possessed by graviola "promising."

Graviola stops breast cancer as well :Nutrition and Cancer experts confirms the cancer- inhibiting phytochemicals in graviola. The medical journal's June 2011 issue includes a study on graviola and breast cancer. In this study, scientists at Virginia Tech demonstrated that graviola fruit extract (juice) could reduce the growth of cancer on the skin of human breastcancer patients without damaging healthy breast tissue.

Mice who took 200 mg graviola fruit extract per kilogram of food in their diet for five weeks had a significant reduction in protein expression in breast cancer tumors. Overall, graviola extract was able to reduce tumor growth by 32 percent.

Graviola benefits do not stop at cancer.
Memorial Sloan-Kettering Cancer Center has a new page on its website describing the health benefits of graviola. Besides slowing cancer, MSKCC gives clinical evidence that graviola also fights viruses, kills parasites, reduces inflammation, and reverses the glycemic load which leads to diabetes.
These medical studies suggest that graviola extract may be useful to treat herpes simplex virus-1 (Journal of Ethnopharmacology, 1998) and other viral infections.

Graviola is associated with neurotoxicity in one people group
For most people, the graviola, or sour sop fruit, is considered a stand-alone dessert fruit with a flavor described as strawberry-pineapple mixed with coconut or banana cream. It is a popular flavor for juices and ice cream in Central American countries.

However, the fruit has been associated with a neurological disease similar to Parkinson's disease on the Caribbean Island of Guadeloupe, according to several studies, including one published in a 2006 article of the Journal of Neural Transmission.

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Sources: Memorial- Sloane Kettering Cancer Center
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Benefits of Graviola Leaf

Benefits of Graviola Leaf

Edible fruit of the graviola tree has a subtle citrus flavor and the leaves may prevent cancer.
Traditional medicines use leaves from the graviola tree, common in tropical forests, to treat conditions such as cancer and infections. Graviola's scientific name is annona muricata and, it's commonly called soursop, guanabana, Brazilian paw paw or custard apple. If you live in a tropical climate where the trees grow, you can use two or three fresh leaves to brew tea. Otherwise, you can purchase capsule, tablet or tincture supplements of graviola in health stores.

Cancer Prevention
The leaves of the graviola tree have powerful anti-cancer properties coming from phytochemicals in the plant. The journal "Cancer Letters" published a study looking at the impact of graviola on pancreatic cancer. Supplementing with graviola stopped cancerous pancreatic tumor cells from replicating and caused them to die. Researchers suggest this natural medicine may prevent and treat cancer. The leaves may also be useful for treating skin cancer when applied topically.

Treating Viral Infections
Traditional medicines use graviola leaves as treatment for viral infections. An article published in "The Journal of Ethnopharmacology" in May of 1998 found that extracts from the leaves suppressed the herpes simplex virus. The herpes virus is spread through bodily fluids and often transmitted while kissing or through sexual contact. According the University of Maryland Medical Center, up to 90 percent of the U.S. population has been exposed to one form of the virus and there is no cure. Some anti-viral medications can reduce the number of outbreaks or lessen symptoms. More research is needed to determine what role graviola can play in the treatment or prevention of herpes.

Pain Reduction
Supplementing with graviola leaves may reduce swelling and pain, according to a study published in May of 2010 in the "International Journal of Molecular Sciences." Researchers gave mice with burned paws extracts of graviola leaf and observed their behaviors. Those given the supplement had less swelling and demonstrated fewer indications of pain. However, more research is needed to determine the safety and efficacy of this use in humans.

Possible Side Effects
No established human dosage for graviola leaf exists yet. Long-term or high-dose supplementation may cause damage to the myelin sheath, disrupting normal nerve function. Movement disorders may also occur because of compounds called alkaloids present in the plant. Symptoms of these conditions are similar to those of Parkinson's disease. Talk with your health care provider prior to taking a graviola leaf supplement.

Source: Erica Kannall, Demand Media

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Monday, 28 December 2015

Health Benefits of Red Palm Oil

Some Red Palm Oil (Unbleached) Facts

Red Palm Oil

*Red Palm oil has a long history of dietary use spanning over 5000 years just like olive oil. Highly organic and traditionally produced through a simple non-chemical process.

*Palm oil is high in both saturates (49%) and unsaturates (51%) but its saturates content is not classified with those found in animals.

*Palm oil is cholesterol free!

*Palm oil is increasingly being used by food manufacturers as a healthier substitute for trans-fat.

*Palm oil is rich in tocopherols and tocotrienols (precursor for vitamin E) and carotenes (pro-Vitamin A)

*Palm oil saturates and unsaturates separate into two layers at room temperature. The saturates are solid and unsaturates remain liquid on the top layer.

*Palm oil saturates are excellent for frying with lower tendency to oxidise.

*Palm oil is readily digestible and absorbed to be utilised as a source of energy.

In a recent research, it was found that Palm oil did not contribute to a rise in body cholesterol but actually significantly reduced lipoprotein in the blood plasma of those who regularly used it as the main source of their dietary fat

Health Benefits of Red Palm Oil

Red Palm Oil, the staple oil in the Africa and Asia continents, naturally contains unique phytonutrients that are proven to be beneficial to human health. The oil palm (Elaeis guineensis), from which red palm oil is derived contains the phytonutrients tocotrienols (vitamin E), mixed carotenoids, phytosterols, squalene and coenzyme Q10 (CoQ10). Of these, the tocotrienols and carotenoids in particular, are proven to confer health benefits such as potent cardioprotection, neuroprotection and skin nutrition; as mentioned by Dr. Mehmet Oz in his recent TV program, where he called it his most miraculous find in 2013 to address the aging process.

Scientific evidence (more than 700 published papers) have shown tocotrienols together with the phytonutrients from red palm oil contribute to these health benefits.

The two main phytonutrients concentrated from red palm oil and available as commercial extracts in the market are tocotrienols and carotenes complex.  Both full-spectrum palm tocotrienol complex and carotenoids complex , are GRAS (generally recognized as safe) according to Title 21 Code of Federal Regulation for use in foods and drinks, with a “No Objection Letter" from FDA.  In addition, these products are not genetically modified and are vegetarian, kosher and halal certified.

Tocotrienols are members of the vitamin E family. In the body, vitamin E acts as an antioxidant that protects lipid from peroxidation and help quench free radicals. However, there is a difference in antioxidant potency between tocotrienol and its sibling tocopherol. Tocotrienol has been shown to be 40 to 60 times more potent than tocopherol as an antioxidant. Similar to the tocopherols, tocotrienols consist of 4 members: alpha, beta, gamma, and delta isomers.1 Structurally, both tocotrienol and tocopherol possess a chromanol head attached to a carbon side chain. Tocotrienol has three double bonds in its side chain, but tocopherol has a saturated tail. Many studies have suggested that this polyunsaturation in tocotrienols contributes to more potent effects than tocopherols.

Research shows tocotrienols are beneficial to consumers who want to maintain healthy brain (neuroprotection), blood lipid levels, arterial compliance (by reducing arterial stiffness), liver health, skin nutrition and immune protection.

The deep orange red color of red palm oil is contributed by natural pigments called carotenoids. There are more than 600 different carotenoids known to exist in nature. Carotenoids have long been used as natural food colorants in food and drinks, as well as cosmetics. Red palm oil is a natural plant source of carotenes in terms of retinol (vitamin A) equivalents, providing 7,000 retinol equivalents (RE) per 100 grams. This is about 17 times as much beta-carotene as carrots, in terms of retinol equivalents. Some carotenoids, such as beta-carotene and alpha-carotene, act as precursor of vitamin A. Lycopene, lutein, zeaxanthin are carotenoids that do not have vitamin A activity, but possess other health-promoting biological properties. The primary forms of carotenoids in red palm oil are beta-carotene, alpha-carotene, gamma-carotene and lycopene. Palm oil contains the highest alpha-carotene level among all the plant sources.

There are four main commercial sources of carotenoids, namely synthetic beta-carotene, algae’s beta-carotene, fermentative beta-carotene and palm carotenoids. Synthetic beta-carotene is an artificial colorant containing only a single form of isomer (all trans beta-carotene). Likewise, algae’s and fermentative beta-carotenes predominantly contain a single isomer (more than 96 percent as beta-carotene), which are not true mixed carotenoids complex.

In comparison, palm carotenoids complex is a fruit/food-based natural carotenoid. Natural palm carotenoids complex is extracted from palm fruits via a mild extraction process, which ensures maximum natural preservation of carotenoids. Apart from beta-carotene, palm carotenoids complex contains the highest level of alpha-carotene compared to carotenoids from other sources. It also contains appreciable amount of gamma-carotene and lycopene.

Commercial Sources of Carotenoids

Palm  Carotenoid Complex

Algae beta-carotene






Crude palm oil
(Elaeis guinnensis)
(D. salina)
(B. trispora)

33% alpha-carotene
65% beta-carotene
2% other carotenoids (mixed carotenoid complex)
> 96%
beta-carotene (predominantly a single beta-carotene source)
> 98%
beta-carotene (predominantly a single beta-carotene source)
beta-carotene (single beta-carotene source)

Highest level of alpha-carotene
(33 to 35%)
Negligible level of alpha-carotene
Negligible level of alpha-carotene
No alpha-carotene
Cis and trans isomers

Cis and trans
Cis and trans
~ 100% trans
100% trans

A series of NIH-funded research that spanned longer than  a decade showed tocotrienols (as Tocomin SupraBio®, from Carotech Inc.) support brain health by triggering and increasing blood circulation through collateral arteries to the area of the brain that suffered ischemic stroke.  In addition, oral supplementation with Tocomin SupraBio® in human subjects showed tocotrienols are well absorbed and distributed to organs and tissues, such as the brain, liver, heart muscle, adipose tissue, blood and skin; reaching levels that more than enough to confer neuroprotection.

Based on these encouraging and significant results,  a clinical trial named “NUTRITION," which is the acronym for “Natural Tocotrienol Against Ischemic Stroke Event," has been commissioned and is now been carried out at  the Ohio State University Medical Center. NUTRITION will evaluate the effects of orally supplemented natural full spectrum palm tocotrienol complex (as Tocomin SupraBio) on platelet function and blood lipid profile including high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol. Dyslipidemia and hypercoagulable are established risk factors of stroke. This study aims to clarify the potential of full-spectrum palm tocotrienol complex to mitigate these important stroke risks.


Peer review journals have documented palm tocotrienol complex’s promising hypocholesterolemic properties.

A recent double blind, placebo-controlled clinical trial shows that subjects with high blood cholesterol who received Tocomin SupraBio demonstrated significant reduction in total and LDL cholesterol levels within four month of supplementation. Continuous significant reduction was seen on the fifth and sixth month. In contrast, subjects in the placebo group had negligible changes in their total and LDL cholesterol levels compared to baseline.

High blood pressure or hypertension is one of the major risk factors of cardiovascular diseases and strokes. In a human clinical trial, patients supplemented with palm tocotrienol complex for two months resulted in significant reduction in aortic systolic blood pressure.

Decreased arterial compliance or increased arterial stiffness is a predictor of cardiovascular events in both normal and diseased human subjects. A randomized controlled clinical trial demonstrated that oral supplementation of Tocomin SupraBio for two months reduced arterial stiffness in healthy adults.

In a prospective, cross-sectional, population-based study involving a randomly selected population sample of 392 men and women aged 45-65 (The BRUNECK study), the relationship between atherosclerosis (carotid and femoral artery) risk and plasma alpha- and beta-carotene level (mixed carotenoids) was evaluated. This study provided evidence that atherosclerosis risk was inversely related to plasma alpha- and beta-carotene levels, indicating a protective role of high levels of carotenes against atherogenesis.

Skin Nutrition

Vitamin E, synthetic or natural, is widely used in the cosmetic/personal care industry. The main reason for the use of vitamin E was for its antioxidant properties in the protection of skin against the onslaught of free radicals or oxidative stress caused by chemical insult and UV rays in our daily atmosphere. Most of the vitamin E used in cosmetic is mainly of the tocopherol form (synthetic and natural forms).

Fueled by the many recent scientific publications on the benefits of tocotrienols in cosmetic application and women's health, the use of tocotrienols has been gaining tremendous attention in the oral and topical cosmetic and personal care industry. Exciting science and research are being conducted on tocotrienol for its superior protection of skin and skin aging compared to tocopherol as well as the skin’s first line of defense against free radicals.

Dr. Nicholas Perricone, dermatologist at the Yale Medical Center, in his New York Times' best-selling book, "The Wrinkle Cure," advocated the use of tocotrienols in cream to promote skin health and prevent skin aging.

The research on tocotrienols in the protection of skin has been fairly new, i.e., less than 15 years. More research is currently being conducted either by companies or universities to understand and evaluate the efficacy of tocotrienols in skin protection and skin nourishment. Scientists believe tocotrienols play a major and important role in the protection of the skin, especially in the prevention of oxidative stress and skin anti-aging and wound-healing.

Liver Health

A recent human clinical study completed at The Ohio State Universtiy Medical Center also reported that end-stage liver patients (those waiting for liver transplantation) supplemented with Tocomin SupraBio resulted in statistically significant protective effects.Another group of researcher in Malaysia also reported that taking 200 mg of Tocomin SupraBio twice a day was significantly effective in addressing fatty liver. This study was presented at the Liver Meeting of the American Association for the Study of Liver Diseases (ASSLD) in Boston in 2010.

Source of Vitamin A

Research has shown consumption of red palm oil significantly enhanced vitamin A levels in humans, and it is beneficial in preventing vitamin A deficiency. Vitamin A deficiency may lead to blindness, skin disease and weakened immune function.

The human body is able to convert provitamin-A carotenoids (alpha- and beta-carotene) when there is a deficiency, hence it is safer to supplement with carotenes than consuming vitamin A (retinoids) directly. Excessive consumption of retinoids may lead to toxicity with symptoms ranging from mild, such as headache, nausea and dry, itchy skin to severe, such as liver damage.

Natural Food Color

Palm fruit carotenoids are widely used in the fat- and dairy-processing industry to standardize the color of margarine, butter and ghee. They are also widely used as a natural colorant in confectionery and convenience foods; and to replace synthetic colorants in the beverage industry. The trend, especially in Europe, the United States and Japan, is moving toward replacing synthetic with natural colorants.

Potent Antioxidant

Carotenoids are potent antioxidants. Professor Lester Packer of the University California Berkeley showed alpha-carotene is a more potent antioxidant than beta-carotene .

Red palm oil is rich in natural phytonutrients that are important for health. These phytonutrients (ie : tocotrienols and carotenes) are also powerful antioxidants that help maintain the stability of the oil during cooking process and may extend the shelf life of food prepared with red palm oil.

Numerous scientific studies have shown how tocotrienols and carotenoids work in supporting important health conditions, especially in supporting brain and heart health, liver health as well as skin nutrition. However, in all these research, a common and important thread for positive effects has been the naturally-attained full spectrum tocotrienols or carotenoids complex. There have been negative studies for both vitamin E (ie : alpha-tocopherol) and beta-carotene in the past, due to the fact that those studies only used a single form (isomer) of the nutrient. The market is moving towards taking what nature produces – as a wholesome complex of ingredients, naturally found in our diet as opposed to a single ingredient formulation. Therefore, it is important to use what nature produces – as the combination of nutrients naturally found in red palm oil work synergistically to confer the optimum functionality and health benefits.

Bryan See is the product manager of Carotech . He has a bachelor’s degree of science in food technology from the University Science Malaysia. He has been working at Carotech for the past seven  years, as product manager for the Asia Market and more recently as a product manager for the U.S. market. His knowledge and experience on tocotrienols (Tocomin®) and carotenoids (Caromin®) as well as palm oil are gained from Carotech, a GMP (good manufacturing practice)-certified palm tocotrienols and carotenoids.

Source: Natural Products Insider

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Sunday, 27 December 2015

Top 15 Home Remedies for Vaginal Odor

Remedies for vaginal odor 

Have you recently experienced a foul smelling discharge from your vagina? If yes, it may mean that there is an overgrowth of yeast or bacteria giving birth to your vaginal odor. Medically known as Bacterial Vaginosis (BV) and Vaginal Yeast Infections, vaginal odor can be sometimes embarrassing though it should not be. According to the American College of Obstetrics and Gynecology, feminine odor changes throughout the normal monthly menstrual cycle of a woman. Just as your feet or breath has a smell, vagina too has a smell due to the presence of bacteria here. However, this may get unusual and you may get metallic or musty smell or even a fishy smell from vagina which can be due to foods you eat or certain hormonal causes along with the overgrowth of bacteria as well as sexually transmitted diseases for which you should get treatment. Accompanied by yellow or white discharge, itching, burning and irritation, vaginal odor may indicate vaginal infection. If your vaginal odor, however, doesn’t indicate anything serious, you may apply some home remedies for vaginal odor to get rid of this foul smell.

Home Remedies for Vaginal Odor

1. Fenugreek Remedies for Vaginal Odor
Fenugreek is a wonderful herb that cures many conditions including vaginal odor. Fenugreek is especially beneficial for women’s health as it promotes hormonal balance as well as regular menstrual cycle if consumed on a regular basis. Some herbalists even claim that the properties of fenugreek are almost similar to those of female sex hormone, estrogen. These are some of the ways you can use fenugreek to reduce your vaginal odor.

Ways to Use Fenugreek for Vaginal Odor
Drink Fenugreek Soaked Water
Get this:
Fenugreek seeds- 1-2 tsp
Water- 1 glass

Do this:
Take fenugreek seeds and soak in water overnight.
In the morning, strain the water and drink it on an empty stomach.
Do this daily for about 2 weeks.

Make Fenugreek tea
Get this:
Fenugreek seeds- 1 tbsp
Water- 1 cup
Do this:
Crush the fenugreek seeds, preferably with the help of mortar and pestle. Use any other way to crush them if you don’t have mortar and pestle.
Boil the water in a pan and put off the flame.
Add crushed fenugreek seeds to the hot water and cover.
Let it steep for about 10-15 minutes. You may steep fenugreek for upto 3 hours.
Drink this hot (or cold, if you’ve steeped for longer) fenugreek tea.
Wash Vagina with Fenugreek Water
Get this:
Fenugreek seeds- 2-3 tsp
Water- 1 liter
Do this:
Add fenugreek seeds to water.
Boil this water on medium flame for about half an hour.
Let the water cool down.
Wash your vagina with this water.
Do this 3-4 times a day.
Take Precaution: Fenugreek may induce gastrointestinal discomforts like diarrhea or bloating, allergic reactions, and nausea. Also topical application may lead to skin rashes or irritation. So check your tolerance before applying these fenugreek remedies for vaginal odor. Avoid using this if you are pregnant as it may induce premature labor. If you are Hypogycemic, avoid having fenugreek as it reduces blood sugar level.

2. Yogurt- the Natural Remedy for Vaginal Odor
With all its health benefits, yogurt can also help you get rid of vaginal odor. Yogurt is naturally rich in lactobacillus, the healthy bacteria which not only keeps your stomach free of any infection but also reduce the yeast infection of your vagina. Lactobacillus also helps in restoring normal vaginal pH level which kills your vaginal odor. So eat unsweetened plain yogurt everyday, as much as two cups a day. You may also use yogurt in other ways to get rid of your vaginal odor.
Ways to use Yogurt for Vaginal Odor
Consume Yogurt Daily
This is the best way to use yogurt not only for vaginal odor elimination but also for your overall health. Just take care to have organic, unflavored, unsweetened yogurt. Sweetened yogurt can actually increase your problems by promoting yeast infection. It’s better to have plain yogurt. If you are buying probiotic yogurt, check if it contains lactobacillus or not because this is the healthy bacteria in yogurt which will get you rid of your vaginal odor. Have at least 2 cups of yogurt everyday.
Apply Yogurt to Vagina
Yogurt- ¼ – ½ cup
Cotton pad
Do this:
Take the yogurt in a cup or bowl.
Dip the cotton pad in the yogurt and let it soak well.
Now take the cotton pad out of the yogurt.
Apply this yogurt to your vagina by rubbing with gentle hand.
Let it be there for sometime, wash off with water and pat dry.
Repeat this for three to four times a day.
Alternatively, you may soak a tampon in plain yogurt and insert in your vagina. Leave it there for sometime before removing. Now wash off with plain water.
Take Precaution: If you are allergic to dairy products, avoid having or using yogurt for vaginal odor.

3. Garlic Remedies for Vaginal Odor
Garlic is a known natural anti-bacterial herb. Having garlic can get you rid of bad bacteria that cause vaginal odor. The strong antifungal properties of garlic also help eliminate the plethora of fungus causing yeast infection and giving rise to mild vaginal odor.
Ways to Use Garlic for Vaginal Odor
Eat 1-2 raw garlic cloves with one glass of warm water in the morning on an empty stomach.
Insert one clove of peeled garlic into your vagina and leave for a couple of hours. Wash or take bath after removing the garlic clove. Do this once or twice a week to get rid of vaginal odor.
Include garlic in your dishes like salads and dips.
Crush some garlic cloves to make paste. Apply this garlic paste to your vagina and leave for about 10 minutes. Wash or have bath after this.

4. Apple Cider Vinegar to Treat Vaginal Odor
Apple cider vinegar (ACV) is one ingredient which has been studied widely for its health benefits. Many studies have found apple cider vinegar useful in treating vaginal infections too. ACV has fine anti-fungal and anti-microbial properties that are responsible for its curative nature. Also apple cider vinegar balances pH levels in an effective way and that’s one reason why you can use apple cider vinegar to get rid of your vaginal odor.
How to Use Apple Cider Vinegar for Vaginal Odor
Get this:
Apple cider vinegar- 3 cups
Warm water- enough for a shallow bath
Do this:
Fill your bath tub with warm water.
Add apple cider vinegar to this water.
Now sit in this water for about 20-30 minutes.
If you badly suffer from vaginal odor, you may apply this remedy 4-5 times a week otherwise do it just once or twice a week.
Other Ways to Use Apple Cider Vinegar for Vaginal Odor
If you do not want to use ACV this way, you may use it in some other ways mentioned here.
Dilute some apple cider vinegar with water and rinse your vagina with this diluted solution.
Soak a tampon in diluted solution of apple cider vinegar and insert this into your vagina to keep it there for 30-60 minutes.
Mix 1 ounce of ACV with 8 ounces of water and drink this daily to balance pH level of your body. This prevents overgrowth of bacteria in your body including vagina.

5. Tea Tree Oil to Get Rid of Vaginal Odor
Tea tree oil is a known natural antiseptic. It gets you rid of germs and bacteria very fast. However, never use undiluted tea tree oil directly on skin as this may lead to irritation and burning sensation. Just a few drops of this strong antiseptic and antibacterial oil mixed with some water is enough to cure your vaginal odor.
Ways to Use Tea Tree Oil for Vaginal Odor
Mix 4-5 drops of tea tree oil to water in bath tub. Sit in this water for 20-30 minutes. Wash with plain water afterwards and pat dry. Do not use soap to wash your vagina after using this remedy. Do this 2-3 times a day.
Rinse your vagina with water mixed with 2-3 drops of tea tree oil. Do this 2-4 times a day.
Add few drops of tea tree oil to some water and soak a tampon. Insert this tampon into your vagina and leave for about 5 minutes before taking it out. Do this an hour before you take bath. Repeat this daily for a week or so.

6. Baking Soda Remedies for Vaginal Odor
One of the causes of vaginal odor is imbalanced pH level of your body. Baking soda can instantly level your pH level. So, when you are up to go out and realize your vagina is emitting foul smell, drink a glass of water mixed with some baking soda. You may actually like to use baking soda to wash your vaginal area regularly to keep its pH levels balanced.
Ways to Use baking Soda for Vaginal Odor
Take 1-2 tsp of baking soda and mix this with a glass of water. Drink this daily.
Add half a cup of baking soda to water in your bath tub. Sit in this water for about 20 minutes. This treats yeast infection and instantly eliminates vaginal odor.

7. Cranberry Juice to Remove Vaginal Odor
Cranberries have been known for their efficiency in detoxifying body. As cranberry juice is acidic in nature, it helps keep bacteria count low in your body. This is also why drinking cranberry juice is an established natural remedy for urinary tract infections. Just a glass of unsweetened and undiluted cranberry juice may help flush toxins from your body as well as keep vaginal odor at bay!

8. Alum Remedies for Vaginal Odor
Alum is a sulfate of aluminum and apart from being used for food pickling and purifying water, it is also used for controlling body odor. In fact, it is a traditional natural aftershave to control bleeding from cuts that men can get from shaving. As it easily dissolves in water, alum can mix with sweat to neutralize the development of bacteria that cause body odor. As far as vaginal odor is concerned, the antiseptic and astringent properties of alum come into play to restrict the growth of bacteria that give rise to foul smell in your vagina. Alum is especially beneficial when vaginal odor is due to whitish liquid vaginal discharge (Leucorrhoea).
Ways to Use Alum for Vaginal Odor
Mix ¼ to ½ tsp of alum powder in some water and use this for washing your vagina and surrounding area.
Get an alum stick from any grocery store. Soak it in water and rub it on your vagina’s mouth with gentle hand. Don’t be too harsh. Do it 1-2 times a day.
Mix ¼ tsp of alum powder with a glass of water and have it twice a day. This remedy treats leucorrhoea and eliminates excessive vaginal discharge that give rise to bad smell.

9. Guava Leaves Remedy for Vaginal Odor
Guava leaves have antioxidants, antibacterial, and anti-inflammatory properties along with certain beneficial tannins. These leaves have been used traditionally for medicinal uses in various diseases. While guavas help reduce menstrual cramps in women, guava leaves when boiled with water give an excellent solution to cure vaginal discharge problems.
How to Use Guava Leaves for Vaginal Odor
Get this:
Guava leaves- 8-10
Water- 1 liter
Do this:
Add guava leaves to water.
Boil this water till it reduces to half its quantity.
Let it cool down.
Strain and use the water for washing your vaginal area. Rinse your vagina throughly with this water.
Do this twice a day.

10. Indian Gooseberry to Cure Vaginal Odor
Amla or the popular Indian gooseberry has many properties apart from being one of the richest sources of Vitamin C. It is an effective natural blood purifier. Just by eating amla can get you rid of vaginal odor and other infections. It is an established natural remedy to treat Leucorrhoea or vaginal discharge which gives rise to foul smell. You can eat raw amla, amla powder mixed with water or even pickled amla. Here are a couple of ways to use gooseberry to treat leucorrhea which is one of the causes of vaginal odor.
Ways to Use Amla to Cure Leucorrhea induced Vaginal odor
Add 1 tsp of amla powder to 1- ½ tsp of honey. Mix well to make a paste and have this twice a day for at least one month.
Take 4-5 tsp of amla juice and mix ½ tsp of honey with this. Have this twice a day for one month.

11. Make Herbal Capsule for Odor from Bacterial Vaginosis
Bacterial vaginosis, as mentioned earlier, is caused by imbalance in bacteria present in your vagina. Normal lactobacilli, the good bacteria, decrease in the vagina which increases the vaginal pH. This increase in pH level results into an overgrowth of anaerobic bacteria in the vagina which causes discomforts including itching and foul smell. Here is one herbal remedy which is used to make capsules with the help of a variety of herbs to cure bacterial vaginosis and get you rid of vaginal odor.
Get this:
Echinacea root powder- 1 part
Yellow Dock root powder- 1 part
Slippery Elm bark powder- 1 part
Comfrey root powder- 1 part
Golden Seal root powder- 2 part
Myrrh gum powder- 1 part
“00” gelatin capsules
Parts of these herbal powders are to be taken by weight and not by volume.

Do this:
Mix all the herbal powders.
Now fill the gelatin capsules with this herbal mix. “00” size capsules hold about 735 mg. You will need about 1 teaspoon mixture to fill 5 such capsules.
After you prepare your herbal capsules, store them safely.
Have 2 capsules three times daily.
Do this for 1-2 weeks.

12. Boric Acid Remedy to Treat Vaginal Odor
Now you know that the good bacteria lactobacillus stay in your vagina to keep its acidity in check. However, certain substances like menstrual blood or semen etc. affect the acidity of vagina and make it more alkaline. The pH level of vagina gets affected negatively and the increased alkalinity contribute to the growth of bacteria leading to bacterial vaginosis. Boric acid, which is mildly acidic and antiseptic can help in restoring the correct acidic level in your vagina.
How to Use Boric Acid to Cure BV induced Vaginal Odor
Get this:
Boric acid
Size “00” gelatin capsules
Do this:
Take the gelatin capsules and fill them with boric acid.
Store them safely.
Insert 1 capsule filled with boric acid into your vagina at bedtime.
Do this once or twice a week.
The natural remedy for vaginal odor using boric acid is more of a preventive measure which protects you from getting bacterial vaginosis if you are prone to this. However, if you feel that you are about to develop BV, increase the dose of boric acid capsule by using 1 capsule for 3 consecutive nights. After this, again start using the capsule once or twice a week.
Warning: Ensure you never swallow the gelatin capsules with boric acid. Put a clear label on the bottle in which you store boric acid capsules and keep it out of reach of children. If you are pregnant, never use boric acid capsules in your vagina too.

13. Neem-Margosa Leaves Remedy for Vaginal Odor
The herb Neem, also known as Margosa, has excellent antifungal, antiviral and antibacterial properties. Neem bark extract as well as leaves are especially effective in protecting you against various fungi including candida which leads to yeast infections that in turn give rise to vaginal odor. Ayurveda, the ancient Indian medicine, prescribes neem remedy to treat bacterial vaginosis. Here is how you can use margosa leaves to get rid of BV as well as vaginal odor.
Get this:
Neem leaves- a handful
Water- enough to make paste
Do this:
Heat a pan.
Add neem leaves to the pan and dry roast for about three minutes.
Put off the flame and let the leaves cool down.
Once cold, crush the roasted neem leaves to get a fine powder.
Take 2 tsp of this neem leaves powder.
Add a little water to this and make a paste.
Apply this neem leaves paste to your vagina and surrounding area.
Do this twice a day.

14. Turmeric-Milk Remedy for Vaginal Odor
Turmeric is one of the best herbs for many ailments. It is a natural anti-bacterial that kills bacteria and keeps your vagina protected against viral infections. One of the Ayurvedic remedies for vaginal odor induced by bacterial vaginosis as well as dryness in vagina suggests using milk and turmeric.
Get this:
Milk (warm)- 1 glass
Turmeric powder- 1 tsp
Do this:
Add turmeric poweder to warm milk.
Mix well and drink this.
Drink this turmeric mixed milk daily till your vaginal odor and infection is cured.

15. Hygiene and Diet Remedies for Vaginal Odor
Apart from the natural and herbal ingredients that prevent and cure foul smell, there are many other factors that decide whether you will suffer from vaginal odor and other vagina related issues or not. These include foods that you eat and hygiene that you maintain. Here are some cleanliness, hygiene and diet remedies for vaginal odor that will go a long way to make you feel relieved and refreshed.
Drink lots of water during the day. Water gets your body rid of bad toxins and harmful bacteria.
Avoid caffeine drinks like coffee and tea as well as sugary drinks like colas etc. Excessive sugar in your body give way to bacteria and in turn vaginal odor.
Avoid too spicy and starchy foods.
Have lots of citrus foods that are rich in vitamin C such as guava, grapes, oranges, sweet lime, lemons, grapefruits, pineapples etc. Vitamin C boosts your immune system and prepares your body to fight against harmful bacteria.
Avoid unprotected sex which may cause infections and sexually transmitted diseases, one of the leading causes of vaginal odor.
Wear underwear made of breathable fabric like cotton. Change them everyday and wash them properly with soap.
During monthly menstrual cycle, change sanitary pads frequently. If using tampons, don’t forget to take them out.
Wash your vagina properly after intercourse and urination.
Always wear lose fitting clothes. Tight jeans or pants don’t allow air to flow and result in sweating which gives rise to vaginal odor.

Source: Rapid home remedies

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